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These data were featured in a late-breaking, oral presentation at the 31st European Academy of Dermatology and Venerology (EADV) Congress.

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Evaluation of the Efficacy and Safety of Lebrikizumab (LY3650150) in Moderate to Severe Atopic Dermatitis (ADvocate1)

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Evaluation of the Efficacy and Safety of Lebrikizumab (LY3650150) in Moderate to Severe Atopic Dermatitis (ADvocate2)

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Study Design

Go to sections

Study Type : Interventional (Clinical Trial)

Estimated Enrollment : 120 participants

Allocation: N/A

Intervention Model: Single Group Assignment

Masking: None (Open Label)

Primary Purpose: Treatment

Official Title: An Open-Label, Study to Evaluate the Safety and Efficacy of Lebrikizumab in Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis Previously Treated With Dupilumab

Estimated Study Start Date : August 18, 2022

Estimated Primary Completion Date : August 2, 2023

Estimated Study Completion Date : December 6, 2023

clinicaltrials.gov/ct2/show/NCT05369403?term=Lebrikizumab&draw=2&rank=3

A Study of Lebrikizumab (LY3650150) in Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis Previously Treated With Dupilumab

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------------------

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ASLAN PHARMACEUTICALS LIMITED

September 7, 2022¡P8 min read

In this article:

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ASLAN PHARMACEUTICALS LIMITED

ASLAN PHARMACEUTICALS LIMITED

Data presented at EADV for the first time show eblasakimab suppresses downstream inflammatory biomarkers of atopic dermatitis, continuing 4-6 weeks after the last dose

Notable improvements in quality-of-sleep measures, with fewer patients reporting sleep disturbance on eblasakimab

Eblasakimab significantly reduced P-NRS (itch) scores and improvements continued throughout 8-week course of treatment across all dose cohorts

MENLO PARK, Calif. and SINGAPORE, Sept. 07, 2022 (GLOBE NEWSWIRE) -- ASLAN Pharmaceuticals (NASDAQ: ASLN), a clinical-stage, immunology-focused biopharmaceutical company developing innovative treatments to transform the lives of patients, today announced the presentation of new eblasakimab data at the 2022 European Academy of Dermatology and Venereology (EADV) annual congress in Milan, Italy. Three posters are being presented as e-posters throughout the duration of the congress from September 7 to 10, 2022.

The posters include previously unpublished data on biomarkers and quality-of-life measures, and new, additional analyses of clinical data from the previously reported Phase 1 multiple-ascending dose study of eblasakimab in moderate-to-severe atopic dermatitis (AD).

Alex Kaoukhov, Chief Medical Officer, ASLAN Pharmaceuticals, commented, ¡§The newly presented biomarker data provide a robust, objective basis for the clinical efficacy we observed in the Phase 1 trial of eblasakimab and support its potential to offer a clearly differentiated treatment option for AD patients. We observed significant improvements in itch and sleep loss within the 8-week study period, suggesting the potential for a greater magnitude of effect with prolonged treatment and we are investigating this in the ongoing phase 2b study. Collectively, the data being presented at EADV gives us great confidence to continue investigating eblaskaimab¡¦s role in AD and other indications in the future.¡¨

2022 EADV e-poster details

Poster 1 (Poster #0243)

Eblasakimab, a monoclonal antibody targeting IL-13R£\1, reduces serum biomarkers that are associated with atopy and correlated with disease severity, in patients with moderate-to-severe atopic dermatitis

Discussion

AD is a skin disease with a predominant Type-2-inflammatory signature. Signaling through the Type 2 receptor induces expression of a multitude of marker molecules, correlating with disease severity. Marker molecules such as thymus activation regulated cytokine (TARC/CCL17), immunoglobulin E (IgE), and lactate dehydrogenase (LDH) are elevated in patients with severe disease. The poster shows results of patient samples from the proof-of-concept (PoC) trial of eblasakimab in adults with moderate-to-severe atopic dermatitis. Samples were immunoassayed for serum TARC, IgE and tested for LDH.

Results

Eblasakimab treatment reduced circulating levels of TARC/CCL17, IgE, and LDH, suggesting eblasakimab¡¦s unique mechanism of action targeting IL-13R£\1 and blocking the signaling of IL-4 and IL-13 through the Type 2 receptor is associated with reduced expression of the biomarker molecules associated with disease severity in AD1. Reductions from baseline were observed as early as the first post-baseline assessment for TARC/CCL17 (day 4), IgE (day 15) and LDH (day 15), with a rapid onset and significant difference at week 8 between 600 mg vs placebo for TARC/CCL17 (mean values of ‑62.23 vs ‑17.83, P<0.001). Serum biomarkers generally remained suppressed in the eblasakimab groups for four to six weeks following the last dose.

Poster 2 (Poster #0342)

Eblasakimab improves itch and sleep loss in adult patients with moderate-to-severe atopic dermatitis in a randomized, double-blinded, placebo-controlled, Phase 1 study

Discussion

Chronic itch is a hallmark of AD and occurs in over 80% of patients with the disease2. Itch is the most burdensome symptom reported by patients and is strongly linked to sleep disturbances; in the general population, up to 48% of adults experience sleep disturbances, but in adults with AD this figure is up to 90%3. The poster presents patient reported outcomes from the PoC trial of eblasakimab in adults with moderate-to-severe atopic dermatitis and includes analyses of pruritus numeric rating scale (P-NRS) and Patient Oriented Eczema Measure (POEM) with a single sleep loss component.

Results

Eblasakimab significantly reduced P-NRS scores across all dose cohorts in the modified Intent to Treat (mITT) population and improvements continued throughout the 8-week course of treatment. At week 8, patients in the 600mg dose group showed a 48% improvement in worst itch, versus a 13% improvement in the placebo group (P=0.05). 56% of patients in the 600mg eblasakimab group demonstrated at least a two point mean improvement in sleep loss, a clinically significant improvement in sleep loss, versus 15% in the placebo group.

Poster 3 (Poster #0343)

Eblasakimab improves multiple disease measures in adult patients with moderate-to-severe atopic dermatitis in a randomized, double-blinded, placebo-controlled, Phase 1 study

Discussion

The poster presents results on assessments of clinical signs of AD from the randomized, placebo controlled, double-blinded Phase 1 PoC trial of eblasakimab in adults with moderate-to-severe AD and highlights improvements in disease measures after treatment with eblasakimab. Efficacy assessments include changes in eczema area and severity index (EASI), Investigators Global Assessment (IGA) and Body Surface Area (BSA) score. Patients in the mITT population received eblasakimab at 200 mg (N=4), 400 mg (N=6), 600 mg (N=16) or placebo (N=13).

Results

In the mITT population, significant improvements in EASI score were seen early and progressed throughout the trial compared with placebo, with the 400mg and 600mg dose cohorts producing a greater response than the 200mg dose. At week 8, significant improvements were noted in the mean percentage change from baseline in EASI score in the 600mg group versus placebo (65% vs 27%, P=0.014), and 69% of patients achieved EASI-75 in the eblasakimab 600mg dose group versus 15% on placebo (P=0.005). Eblasakimab was well tolerated with notable improvements also seen in IGA versus placebo (44% vs 15%) in the 600mg group at week 8.

The posters presented at the conference are available to access here.

References

Hamilton JD et al (2021) Clin Exp Allergy 51(7):915‑931

Legat (2021) Frontiers in Med 8:644760

Bawany et al (2021) J Allergy Clin Immunol Pract 9(4):1488-1500

About eblasakimab

Eblasakimab is a potential first-in-class monoclonal antibody targeting the IL-13 receptor, with the potential to deliver a differentiated safety and efficacy profile as well as an improved dosing regimen for atopic dermatitis patients. In September 2021, ASLAN announced positive results from the Phase 1b multiple-ascending-dose study that established proof-of-concept of ASLAN004 and supported its potential as a novel treatment for AD. In January 2022, ASLAN initiated the TREK-AD Phase 2b trial to evaluate the safety and efficacy of eblasakimab in moderate-to-severe AD patients.

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2.Eblasakimab improves multiple disease measures in adult patients with moderate-to-severe atopic dermatitis in a randomized, double-blinded,

placebo-controlled, Phase 1 study

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3.Eblasakimab, a Monoclonal Antibody Targeting IL‑13R£\1 Reduces Serum Biomarkers Associated with

Atopy and Correlated with Disease Severity in Patients With Moderate‑to‑Severe Atopic Dermatitis

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moderate to severe AD.

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ASLAN004 ¤]·Ç³Æ·m¶i¤G½uAD

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Study Design

Go to sections

Study Type : Interventional (Clinical Trial)

Estimated Enrollment : 120 participants

Allocation: N/A

Intervention Model: Single Group Assignment

Masking: None (Open Label)

Primary Purpose: Treatment

Official Title: An Open-Label, Study to Evaluate the Safety and Efficacy of Lebrikizumab in Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis Previously Treated With Dupilumab

Estimated Study Start Date : August 18, 2022

Estimated Primary Completion Date : August 2, 2023

Estimated Study Completion Date : December 6, 2023

clinicaltrials.gov/ct2/show/NCT05369403?term=Lebrikizumab&draw=2&rank=3

A Study of Lebrikizumab (LY3650150) in Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis Previously Treated With Dupilumab

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Inclusion Criteria:

All participants must have prior treatment with dupilumab meeting one of the following conditions:

Participants who stopped dupilumab treatment due to non-response, partial response, loss of efficacy must have been previously treated with dupilumab (at labeled dose level) for at least 4 months.

Participants who stopped dupilumab treatment due to intolerance or adverse events (AEs) to the drug may enter the study with no required prior length of dupilumab treatment.

Participants who stopped dupilumab treatment due to cost or loss of access to dupilumab (for example, insurance coverage) may enter the study with no required prior length of dupilumab treatment.

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ASLAN ­p¹º©ó 2022 ¦~²Ä¥|©u«×¶}©l TREK-DX¡]EblasaKimab ¦b Dupilumab eXperienced AD ±wªÌ¤¤ªº¸ÕÅç¡^¡A¥Hµû¦ô eblasakimab §@¬°´À¥N¥Íª«»s¾¯¹ï¤w°±¤î¨Ï¥Î dupilumab ªvÀøªº¯SÀ³©Ê¥Öª¢ (AD) ±wªÌªºÀø®Ä©M¦w¥þ©Ê

TREK-DX ±N¬ã¨s eblasakimab ¦b±µ¨ü¹L dupilumab ªvÀøªº±wªÌ¤¤ªº¼ç¦b¥Î³~¡A¥H¸É¥R¥¿¦b¶i¦æªº TREK-AD ¸ÕÅç¦b¥Íª«¤Ñ¯uªº±wªÌ¤¤¶i¦æ

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TREK-DX ªº¶i¤@¨B°Q½×±N¦b 2022 ¦~ 9 ¤ë 15 ¤é¤½¥q¥D¿ìªº¬ãµo¤é´Á¶¡¶i¦æ

¥[§QºÖ¥§¨È¦{ªù¬¥©¬§J©M·s¥[©Y¡A2022 ¦~ 9 ¤ë 14 ¤é (GLOBE NEWSWIRE) -- ASLAN Pharmaceuticals (¡§ASLAN¡¨¡A¯Ç´µ¹F§J¥N½X¡GASLN)¡A¤@®aÁ{§É¶¥¬q¡B¥H§K¬Ì¾Ç¬°­«ÂIªº¥Íª«»sÃĤ½¥q¡A¶}µo³Ð·sÀøªk¥H§ïÅܱwªÌªº¥Í¬¡¡A¤µ¤Ñ«Å¥¬¡A¥¦­p¹º±Ò°Ê¤@¶µ·sªº eblasakimab Á{§É¸ÕÅç¡A¥Î©óªvÀø¥H«e±µ¨ü¹L dupilumab ªvÀøªº¦¨¤H±wªÌªº¤¤«×¦Ü­««×¯SÀ³©Ê¥Öª¢ (AD)¡C Eblasakimab ¬O¤@ºØ¼ç¦bªº¤@¬y³æ§J¶©§ÜÅé¡A¹v¦V IL-13 ¨üÅé¡A¨ã¦³´£¨Ñ®t²§¤ÆÀø®Ä©M¦w¥þ©Êªº¼ç¤O¡C ASLAN ¹w­p±N¦b 2022 ¦~²Ä¥|©u«×©Û¶Ò²Ä¤@¦ì±wªÌ°Ñ¥[¸ÕÅç¡C

¡§»P§Ú­Ì¦b¥Íª«ªì©l±wªÌ¤¤¶i¦æªº 2b ´Á¸ÕÅç¬Û¤ñ¡ATREK-DX ±N¨Ï§Ú­Ì¯à°÷µû¦ô eblasakimab ¦b·s±wªÌ¸sÅ餤ªº¿W¯S§@¥Î¾÷¨î¡A¡¨ ASLAN Pharmaceuticals ­º®u°õ¦æ©x Carl Firth ³Õ¤h»¡¡C ¡§§Ú­Ì¬Û«H¡A³\¦h¥H«e±µ¨ü¹L dupilumab ªvÀøªº±wªÌ¥i¥H±q eblasakimab ¤¤¨ü¯q¡A³o¨Ç¼Æ¾Ú¥i¥H¤ä«ù eblasakimab ¦b¥Íª«¾Ç¤Ñ¯u©M¦³¸gÅ窺±wªÌ¸sÅ餤ªº¨Ï¥Î¡C¡¨

TREK-DX ¸ÕÅç¹w­p±N¦b¥_¬ü©Û¶Ò 75 ¦W±wªÌ°Ñ¥[¤@¶µÀH¾÷¡BÂùª¼¡B¦w¼¢¾¯¹ï·Ó¡B¦h¤¤¤ß¸ÕÅç¡A¥Hµû¦ô eblasakimab ¹ï¥ý«e¨Ï¥Î dupilumab ªvÀøªº¤¤«×¦Ü­««× AD ±wªÌªºÀø®Ä©M¦w¥þ©Ê¡C¸Ó¸ÕÅç±N©Û¶Ò¦]¥ô¦ó­ì¦]°±¤î dupilumab ªvÀøªº±wªÌ¡A¥]¬A¹ï AD ªº±±¨î¤£¨¬¡BµLªk³X°Ý©Î¤£¨}¨Æ¥ó¡C¸Ó­p¹º¬O¤½¥q²{¦³¹BÀç­p¹ºªº¤@³¡¤À¡A¹ï¨ä¥ý«e³ø§iªº²{ª÷¶]¹D¨S¦³¼vÅT¡C

¸Ó¸ÕÅç±N¥]¬A 16 ¶gªºªvÀø´Á©M 12 ¶gªº¦w¥þÀH³X´Á¡C¥D­nÀø®Ä²×ÂI¬OÀã¯l­±¿nÄY­«©Ê«ü¼Æ (EASI) µû¤À±q°ò½u¨ì²Ä 16 ¶gªº¦Ê¤À¤ñÅܤơCÃöÁ䪺¦¸­nÀø®Ä²×ÂI¥]¬A¹F¨ì 0¡]²M°£¡^©Î 1¡]´X¥G²M°£¡^ªº¬ã¨sªÌ¥þ§½µû¦ô (IGA) µû¤Àªº±wªÌ¤ñ¨Ò, EASI (EASI-75) ­°§C 75% ©Î§ó¦hªº±wªÌ¤ñ¨Ò¡A¹F¨ì EASI-50 ©M EASI-90 ªº±wªÌ¤ñ¨Ò¡A¥H¤Îæ±Äo®p­ÈªºÅܤơC

¡§ Dupilumab ¦bÃÒ©ú¹v¦V AD ¤¤ªº IL4/IL-13 «H¸¹³q¸ôªº¯q³B¤è­±µo´§¤F­«­n§@¥Î¡CµM¦Ó¡A¤@¨Ç±wªÌ¨S¦³ªí²{¥X¹ï dupilumab ªº³Ì¨Î©Î«ùÄò¤ÏÀ³¡A©Î¥X²{µ²½¤ª¢µ¥¤£¨}¨Æ¥ó¡A¦]¦¹´M¨D¤@ºØ¥i¥H´£¨Ñ§ó°ª¦w¥þ©Ê©M¦³®Ä©Êªº´À¥NªvÀø¤è®×¡A¡¨¨È·à±d»sÃÄ­º®uÀç¾P©x Alex Kaoukhov ³Õ¤h»¡. ¡§¥¿¦p§Ú­Ì¦b¨ä¥L¾AÀ³¯g¡]¦p»È®h¯f¡^¤¤©Ò¨£¡A°w¹ï¦P¤@«H¸¹³q¸ôªº¤£¦P¤À¤l¦¨¤À¥i¯à¾É­P¤£¦PªºÁ{§Éµ²ªG¡A§Ú­Ì¬Û«H eblasakimab ªýÂ_ 2 «¬¨üÅ骺¿W¯S¤èªk¥i¯à¬° dupilumab ¸gÅçÂ×´Iªº±wªÌ´£¨Ñ¦³®ÄªºªvÀø¡C±wªÌ¡C¡¨

ASLAN ÁÙ¦b¶i¦æ TREK-AD ¸ÕÅç¡A³o¬O¤@¶µ¥þ²yÀH¾÷¡BÂùª¼¡B¦w¼¢¾¯¹ï·Ó¡B¾¯¶q½d³òªº 2b ´ÁÁ{§É¸ÕÅç¡A¥Hµû¦ô eblasakimab ¹ï±w¦³¤¤«×¦Ü­««× AD ªº¦¨¤H±wªÌªºÀø®Ä©M¦w¥þ©Ê¡C¬O¥þ¨­ªvÀøªº­Ô¿ïªÌ¡C¸Ó¸ÕÅ窺¤@½u¼Æ¾Ú¹w­p±N¦b 2023 ¦~¤W¥b¦~µo¥¬¡C

ASLAN ºÞ²z¼h±N©ó¬ü°êªF³¡®É¶¡ 2022 ¦~ 9 ¤ë 15 ¤é¬P´Á¥|¤W¤È 10:00 ¦Ü¤U¤È 1:30 ¦b¯Ã¬ù·ç¦N°s©±Á|¿ì¬ãµo (R&D) ¤é¬¡°Ê¡C­n¿Ë¦Û©Î¥HµêÀÀ¤è¦¡°Ñ¥[¬¡°Ê¡A½Ð³æÀ»¦¹³B¶i¦æµù¥U¡C¬¡°Ê©Mºt¥Ü§÷®Æªº­«¼½±N¦b ASLAN Pharmaceutical ºô¯¸ ir.aslanpharma.com/ ªº§ë¸êªÌÃö«Y³¡¤À´£¨Ñ

ASLAN PHARMACEUTICALS LIMITED

ASLAN plans to begin TREK-DX (TRials in EblasaKimab in Dupilumab eXperienced AD patients) in the fourth quarter of 2022 to evaluate the efficacy and safety of eblasakimab as an alternative biologic in atopic dermatitis (AD) patients who have discontinued treatment with dupilumab

TREK-DX will study the potential use of eblasakimab in patients that have been treated with dupilumab, complementing the ongoing TREK-AD trial in biologic naïve patients

Results from both studies could position eblasakimab as the preferred first-choice biologic for the treatment of moderate-to-severe AD

TREK-DX program is part of the Company¡¦s existing operating plan and has no impact on previously-reported cash runway

Further discussion of TREK-DX will take place during the Company-hosted R&D Day on September 15, 2022

MENLO PARK, Calif. and SINGAPORE, Sept. 14, 2022 (GLOBE NEWSWIRE) -- ASLAN Pharmaceuticals (¡§ASLAN¡¨, Nasdaq: ASLN), a clinical-stage, immunology-focused biopharmaceutical company developing innovative treatments to transform the lives of patients, today announced that it plans to initiate a new clinical trial of eblasakimab for the treatment of moderate-to-severe atopic dermatitis (AD) in adult patients who have previously been treated with dupilumab. Eblasakimab is a potential first-in-class monoclonal antibody targeting the IL-13 receptor that has the potential to deliver a differentiated efficacy and safety profile. ASLAN expects to enroll the first patient in the trial in the fourth quarter of 2022.

¡§In contrast to our Phase 2b trial in biologic naïve patients, TREK-DX will allow us to evaluate eblasakimab¡¦s unique mechanism of action in a new patient population,¡¨ said Dr Carl Firth, CEO, ASLAN Pharmaceuticals. ¡§We believe that many patients previously treated with dupilumab can benefit from eblasakimab, and this data could support the use of eblasakimab in both the biologic naïve and experienced patient populations.¡¨

The TREK-DX trial is expected to enroll 75 patients in a randomized, double-blind, placebo-controlled, multicenter trial in North America to evaluate the efficacy and safety of eblasakimab in patients with moderate-to-severe AD previously treated with dupilumab. The trial will enroll patients who have discontinued dupilumab treatment for any reason, including inadequate control of AD, loss of access or an adverse event. The program is part of the Company¡¦s existing operating plan and has no impact on its previously-reported cash runway.

The trial will consist of a 16-week treatment period and a 12-week safety follow-up period. The primary efficacy endpoint is percentage change in Eczema Area Severity Index (EASI) score from baseline to week 16. Key secondary efficacy endpoints include the proportion of patients achieving Investigator Global Assessment (IGA) score of 0 (clear) or 1 (almost clear), proportion of patients with a 75% or greater reduction in EASI (EASI-75), proportion of patients achieving EASI-50 and EASI-90, and changes in peak pruritus.

¡§Dupilumab has played an important role in demonstrating the benefits of targeting the IL4/IL-13 signaling pathway in AD. However, some patients do not demonstrate an optimal or sustained response to dupilumab, or develop adverse events such as conjunctivitis, and thus seek an alternative treatment option that could offer an improved safety and efficacy profile,¡¨ said Dr Alex Kaoukhov, CMO, ASLAN Pharmaceuticals. ¡§As we have seen in other indications, such as psoriasis, targeting different molecular components of the same signaling pathway can lead to different clinical outcomes and we believe that eblasakimab¡¦s unique approach to blocking the Type 2 receptor may offer an effective treatment for dupilumab-experienced patients.¡¨

ASLAN is also conducting the TREK-AD trial, a global randomized, double-blind, placebo-controlled, dose-ranging, Phase 2b clinical trial, to evaluate the efficacy and safety of eblasakimab in adult patients with moderate-to-severe AD who are candidates for systemic therapy. Topline data from this trial is expected in the first half of 2023.

ASLAN¡¦s management is hosting a Research and Development (R&D) Day on Thursday, September 15, 2022, from 10:00am to 1:30pm ET at the St. Regis Hotel in New York. To attend the event in person or virtually, please click here for registration. A replay of the event and presentation materials will be available on the Investor Relations section of ASLAN Pharmaceutical¡¦s website at ir.aslanpharma.com/

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Lebrikizumab 2b AD Á{§É¦¬280¤H¡þ4²Õ¡A¶}¥ß58­Ó¤¤¤ß¡A¥þ¦b¬ü°ê¹Ò¤º¡C

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The offering

Up to 486,543,875 ordinary shares (or 97,308,775 ADSs), including ordinary shares represented by ADSs (as more fully described in the notes following this table), assuming sales of 27,564,102 ADSs in this offering at an offering price of $0.78 per ADS, which was the last reported sale price of ADSs on Nasdaq on September 9, 2022. The actual number of ADSs issued will vary depending on the sales prices under this offering

P.8

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ir.aslanpharma.com/static-files/23962cfa-f7fc-4e06-aede-b9dc4715b463

21¡A000¡A000¬ü¤¸.¤@¤@¤@¤½¶}¥«³õ¶Ò¸ê¡]³Ì°ª¥i¶Ò150¡A000¡A000¬ü¤¸¡^

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§Ú­Ì¤w»P Jefferies LLC ©Î Jefferies ´N¬ü°ê¦s°UªÑ²¼©Î ADS ñ­q¤F¤é´Á¬° 2020 ¦~ 10 ¤ë 9 ¤é¨Ã©ó 2022 ¦~ 9 ¤ë 13 ¤é­×­qªº¯S©w¤½¶}¥«³õ¾P°â¨óij¡A©Î¾P°â¨óij¡A¨C¤@­Ó¥Nªí¤­­Ó´¶³qªÑ¡A¥Ñ¥»©ÛªÑ»¡©ú®Ñ¸É¥R©MÀHªþªº©ÛªÑ»¡©ú®Ñ´£¨Ñ¡C

®Ú¾Ú§Ú­Ì¤§«e´£¥æµ¹ÃÒ¨é¥æ©ö©e­û·|ªºªí®æ F-3 ©MÀHªþ©ÛªÑ»¡©ú®Ñ¡]µù¥UÁn©ú½s¸¹ 333-234405¡^ªº¥ý«eµn°OÁn©ú¡A§Ú­Ì®Ú¾Ú¾P°â¨óij´£¨Ñ©M¥X°â¤FÁ`­p 2220 ¸U¬ü¤¸ªº ADS¡A¥H¤Î©ÛªÑ»¡©ú®Ñ¸É¥R¡A¤é´Á¬° 2020 ¦~ 10 ¤ë 9 ¤é¡A¸g­×­q¡C®Ú¾Ú¾P°â¨óijªº±ø´Ú¡A®Ú¾Ú¥»©ÛªÑ»¡©ú®Ñ¸É¥R¤å¥ó¡A§Ú­Ì¥i¯à·|¤£®É³q¹L§@¬°¾P°â¥N²zªº³Ç´I·ç´£¨Ñ©M¾P°âÁ`µo¦æ»ù®æ°ª¹F 21,500,000 ¬ü¤¸ªº ADS¡C

§Ú­Ìªº ADS ¦b¯Ç´µ¹F§J¥þ²y¥«³õ©Î¯Ç´µ¹F§J¤W¥«¡A¥N½X¬°¡§ASLN¡¨¡C 2022 ¦~ 9 ¤ë 9 ¤é¡A§Ú­Ì ADS ªº³Ì«á³ø§i°â»ù¬°¨C ADS 0.78 ¬ü¤¸¡C

§Ú­Ì¥Ñ«DÃöÁp¤½¥q«ù¦³ªº¬y³q´¶³qªÑ©Î¤½²³«ùªÑ¶qªºÁ`¥«­È¬ù¬° 6470 ¸U¬ü¤¸¡A³o¬O®Ú¾Ú«DÃöÁp¤½¥q«ù¦³ªº 344,042,734 ªÑ¬y³q´¶³qªÑ©M¨CªÑ 0.188 ¬ü¤¸¡]©Î¨CªÑ¬ü°ê¦s°U¾ÌÃÒ 0.94 ¬ü¤¸¡^­pºâ±o¥Xªº) ©ó 2022 ¦~ 8 ¤ë 16 ¤é¦b¯Ç´µ¹F§J³ø§i¡CºI¦Ü¥»©ÛªÑ»¡©ú®Ñ¸É¥R¤é´Á¡A§Ú­Ì©|¥¼®Ú¾Ú¤@¯ë«ü¥Ü I.B.5 ´£¨Ñ¥ô¦óÃÒ¨é¡C F-3 ªí®æ¦b«e 12 ­Ó¤é¾ä¤ë´Á¶¡µ²§ô¡A¥]¬A¥»©ÛªÑ»¡©ú®Ñ¸É¥R¤é´Á¡C®Ú¾Ú¤@¯ë«ü¥O I.B.5¡C®Ú¾Ú F-3 ªí®æ¡A¦b¥ô¦ó±¡ªp¤U¡A¥u­n§Ú­Ìªº¤½²³¦b¥ô¦ó 12 ­Ó¤ë´Á¶¡¤º¡A§Ú­Ì³£¤£·|¥X°â»ù­È¶W¹L§Ú­Ì¤½²³«ùªÑ¤T¤À¤§¤@ªº»ù­È¶W¹L¥»©ÛªÑ»¡©ú®Ñ¸É¥R³¡¤Àªºµù¥UÁn©ú¤¤µn°OªºÃÒ¨é¯B°Ê¤´§C©ó 7500 ¸U¬ü¤¸¡C

US¢C 21¡A000¡A000

American Depositary Shares representing Ordinary Shares

We have entered into a certain Open Market Sale AgreementSM, dated as of October 9, 2020, as amended on September 13, 2022, or Sales Agreement, with Jefferies LLC, or Jefferies, relating to American Depositary Shares, or ADSs, each representing five ordinary shares, offered by this prospectus supplement and the accompanying prospectus. We have offered and sold an aggregate of $22.2 million ADSs under the Sales Agreement pursuant to our prior registration statement on Form F-3 and accompanying prospectus (Registration Statement No. 333- 234405), previously filed with the Securities and Exchange Commission, and the prospectus supplement thereunder, dated October 9, 2020, as amended. In accordance with the terms of the Sales Agreement, pursuant to this prospectus supplement we may offer and sell ADSs having an aggregate offering price of up to $21,500,000 from time to time through Jefferies, acting as sales agent.

Our ADSs are listed on The Nasdaq Global Market, or Nasdaq, under the symbol ¡§ASLN.¡¨ On September 9, 2022, the last reported sale price of our ADSs was $0.78 per ADS.

The aggregate market value of our outstanding ordinary shares held by non-affiliates, or public float, was approximately $64.7 million, which was calculated based on 344,042,734 ordinary shares outstanding held by non-affiliates and a per share price of $0.188 (or $0.94 per ADS) as reported on Nasdaq on August 16, 2022. As of the date of this prospectus supplement, we have not offered any securities pursuant to General Instruction I.B.5. of Form F-3 during the prior 12 calendar month period that ends on, and includes, the date of this prospectus supplement. Pursuant to General Instruction I.B.5. of Form F-3, in no event will we sell securities registered on the registration statement of which this prospectus supplement is a part with a value exceeding more than one-third of our public float in any 12-month period so long as our public float remains below $75.0 million.

¥»¤å¥ó¤À¬°¨â³¡¤À¡C²Ä¤@³¡¤À¬O©ÛªÑ»¡©ú®Ñ¸É¥R¡A¨ä¤¤´y­z¤F¥»¦¸µo¦æªº¨ãÅé±ø´Ú¥H¤Î»P§Ú­Ì©M§Ú­Ìªº·~°È¬ÛÃöªº¬Y¨Ç¨ä¥L¨Æ¶µ¡C²Ä¤G³¡¤À¡A§YÀHªþªº©ÛªÑ»¡©ú®Ñ¡A¥]§t¨Ã³q¹L¤Þ¥Î¦X¨Ö¤F¦³Ãö§Ú­Ìªº­«­n·~°È©M°]°È«H®§¡B§Ú­Ìªº ADS ©M´¶³qªÑªº´y­z¥H¤Î¦³Ãö§Ú­Ì©M¥»¦¸µo¦æªº¬Y¨Ç¨ä¥L«H®§¡C¥»©ÛªÑ»¡©ú®Ñ¸É¥R©MÀHªþªº©ÛªÑ»¡©ú®Ñ¬O§Ú­Ì¨Ï¥Î¡§³f¬[¡¨µù¥Uµ{§Ç¦VÃÒ¨é¥æ©ö©e­û·|©Î SEC ´£¥æªºµù¥UÁn©úªº¤@³¡¤À¡C

®Ú¾Ú³f¬[µù¥U¬yµ{¡A§Ú­Ì¥i¯à·|´£¨ÑÁ`µo¦æ»ù°ª¹F 150,000,000 ¬ü¤¸ªº¬Y¨ÇÃÒ¨é¡C®Ú¾Ú¥»©ÛªÑ»¡©ú®Ñ¸É¥R¡A§Ú­Ì¥i¯à¤£®É´£¨ÑÁ`µo¦æ»ù®æ°ª¹F 21,500,000 ¬ü¤¸ªº ADS¡A»ù®æ©M±ø´Ú¥Ñµo¦æ®Éªº¥«³õ±ø¥ó¨M©w¡C

®Ú¾Ú¥»©ÛªÑ»¡©ú®Ñ¸É¥R¥i¯à¥X°âªº 21,500,000 ¬ü¤¸ ADS ¥]§t¦b®Ú¾Úµn°OÁn©ú¥i¯à¥X°âªº 150,000,000 ¬ü¤¸ÃҨ餤¡C

±zÀ³¾\Ū¥»©ÛªÑ»¡©ú®Ñ¸É¥R©MÀHªþªº©ÛªÑ»¡©ú®Ñ¡A¥]¬A³q¹L¤Þ¥Î¨Ö¤J¥»¤å©M¨ä¤¤ªº©Ò¦³¤å¥ó¡A¥H¤Î¤U¤å¡§±z¥i¥H¦b¦ó³B§ä¨ì§ó¦h«H®§¡¨¤¤´y­zªº¨ä¥L«H®§¡C³o¨Ç¤å¥ó¥]§t±z¦b°µ¥X§ë¸ê¨M©w®ÉÀ³¦Ò¼{ªº­«­n«H®§¡C

¥»©ÛªÑ»¡©ú®Ñ¸É¥R¸É¥R¨Ã§ó·s¤F³q¹L¤Þ¥Î¨Ö¤J¥»©ÛªÑ»¡©ú®Ñ¸É¥R©MÀHªþ©ÛªÑ»¡©ú®Ñªº¤å¥ó¤¤¥]§tªº«H®§¡C¤@¤è­±¡A¦pªG¥»©ÛªÑ»¡©ú®Ñ¸É¥R¤¤¥]§tªº«H®§»P¦b¥»©ÛªÑ»¡©ú®Ñ¸É¥R¤é´Á¤§«e³q¹L¤Þ¥Î¨Ö¤J¥»©ÛªÑ»¡©ú®Ñ¸É¥Rªº¥ô¦ó¤å¥ó¤¤¥]§tªº«H®§¦s¦b½Ä¬ð¡A«h¥t¤@¤è­±¡A±zÀ³¨Ì¿à¥»©ÛªÑ³¹µ{¸É¥R¸ê®Æ¤¤ªº«H®§¡C¦pªG¨ä¤¤¤@¥÷¤å¥ó¤¤ªº¥ô¦óÁn©ú»P¤é´Á¸û±ßªº¥t¤@¥÷¤å¥ó¡]¨Ò¦p¡A³q¹L¤Þ¥Î¨Ö¤J¥»©ÛªÑ»¡©ú®Ñ¸É¥R¤å¥óªº¤å¥ó¡^¤¤ªºÁn©ú¤£¤@­P¡A«h¤é´Á¸û±ßªº¤å¥ó¤¤ªºÁn©ú±N­×§ï©Î¨ú¥N¸û¦­ªºÁn©ú¡C±zÀ³°²©w¥»©ÛªÑ»¡©ú®Ñ¸É¥R¸ê®Æ¡B¥»©ÛªÑ»¡©ú®Ñ¸É¥R¸ê®Æ¤¤¤Þ¥Îªº¤å¥ó¡BÀHªþªº©ÛªÑ»¡©ú®Ñ¥H¤Î§Ú­Ì±ÂÅv¥Î©ó¥»¦¸µo¦æªº¥ô¦ó§K¶O®Ñ­±©ÛªÑ»¡©ú®Ñ¤¤¥X²{ªº«H®§¶È¦b·í¤é·Ç½T¨º¨Ç¦U¦Ûªº¤å¥ó¡C¦Û³o¨Ç¤é´Á¥H¨Ó¡A§Ú­Ìªº·~°È¡B°]°Èª¬ªp¡B¸gÀç·~ÁZ©M«e´º¥i¯à¤wµo¥ÍÅܤơC

This document is in two parts. The first part is the prospectus supplement, which describes the specific terms of this offering and certain other matters relating to us and our business. The second part, the accompanying prospectus, contains and incorporates by reference important business and financial information about us, a description of our ADSs and ordinary shares and certain other information about us and this offering. This prospectus supplement and the accompanying prospectus are part of a registration statement that we filed with the Securities and Exchange Commission, or the SEC, using a ¡§shelf¡¨ registration process. Under the shelf registration process, we may offer certain of our securities having an aggregate offering price of up to $150,000,000. Under this prospectus supplement, we may offer ADSs having an aggregate offering price of up to $21,500,000 from time to time at prices and on terms to be determined by the market conditions at the time of the offering. The $21,500,000 of ADSs that may be sold under this prospectus supplement are included in the $150,000,000 of securities that may be sold under the registration statement. You should read both this prospectus supplement and the accompanying prospectus, including all documents incorporated herein and therein by reference, together with additional information described under ¡§Where You Can Find More Information¡¨ below. These documents contain important information that you should consider when making your investment decision.

This prospectus supplement adds to and updates information contained in the documents incorporated by reference into this prospectus supplement and the accompanying prospectus. To the extent there is a conflict between the information contained in this prospectus supplement, on the one hand, and the information contained in any document incorporated by reference into this prospectus supplement that was filed with the SEC before the date of this prospectus supplement, on the other hand, you should rely on the information in this prospectus supplement. If any statement in one of these documents is inconsistent with a statement in another document having a later date (for example, a document incorporated by reference into this prospectus supplement) the statement in the document having the later date modifies or supersedes the earlier statement. You should assume that the information appearing in this prospectus supplement, the documents incorporated by reference in this prospectus supplement, the accompanying prospectus and in any free writing prospectus that we have authorized for use in connection with this offering, is accurate only as of the date of those respective documents. Our business, financial condition, results of operations and prospects may have changed since those dates.

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¥[§QºÖ¥§¨È¦{ªù¬¥©¬§J©M·s¥[©Y¡A2022 ¦~ 9 ¤ë 13 ¤é (GLOBE NEWSWIRE) -- ASLAN Pharmaceuticals (NASDAQ: ASLN) ¬O¤@®aÁ{§É¶¥¬q¡B¥H§K¬Ì¾Ç¬°­«ÂIªº¥Íª«»sÃĤ½¥q¡A¸Ó¤½¥q¶}µo³Ð·sÀøªk¥H§ïÅܱwªÌªº¥Í¬¡¡A¤µ¤Ñ«Å¥¬¡G 2022 ¦~ 9 ¤ë 28 ¤é¦Ü 10 ¤ë 1 ¤é¦b²üÄõªü©i´µ¯S¤¦Á|¦æªº²Ä 51 ©¡¼Ú¬w¥Ö½§¯f¾Ç¬ã¨s¾Ç·| (ESDR) ·|ij¤W¡A¨â¥÷®i¥Ü eblasakimab ·sÂà¤Æ¼Æ¾ÚªººK­n³Q±µ¨ü¬°³Ì·sªº¹q¤l®ü³ø¡C

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finance.yahoo.com/news/aslan-pharmaceuticals-announces-acceptance-two-110000498.html

ASLAN Pharmaceuticals Announces Acceptance of Two Late-Breaking Abstracts for e-Poster Presentation at the 51st Annual European Society for Dermatological Research Meeting

MENLO PARK, Calif. and SINGAPORE, Sept. 13, 2022 (GLOBE NEWSWIRE) -- ASLAN Pharmaceuticals (NASDAQ: ASLN), a clinical-stage, immunology-focused biopharmaceutical company developing innovative treatments to transform the lives of patients, today announced that two abstracts showcasing new translational data on eblasakimab have been accepted as late-breaking e-posters at the 51st Annual European Society for Dermatological Research (ESDR) Meeting, taking place from September 28 to October 1, 2022, in Amsterdam, Netherlands.

51st Annual European Society for Dermatological Research e-poster details

Poster 1: Spatial localization and functional role of IL-13R£\1 signaling in atopic dermatitis

(abstract ID: LB060)

Poster 2: Insight into novel itch pathways and spontaneous neuronal activity by targeting interleukin-13 receptor alpha 1 (IL-13R£\1) with eblasakimab

(abstract ID: LB061)

Poster availability date: Wednesday, September 28, 2022.

The posters will be available to view online in the Investor Relations section of ASLAN¡¦s website following presentation: ir.aslanpharma.com/.

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ASLAN Pharmaceuticals Limited (NASDAQ:ASLN) rose 13.3% to $0.8850 in pre-market trading. ASLAN Pharmaceuticals, last week, presented new data on Eblasakimab in multiple posters at European Academy of Dermatology and Venereology Congress.

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H.C. Wainwright 24th Annual Global Investment Conference - September 12-14, 2022

ASLAN Pharmaceuticals

Live on Monday, 9/12 at 10:30 AM (Eastern Standard Time)

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First Name

Last Name

Company

Email

you@example.com

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Dupilumab ¤wÀòAD&EoE ¤G±iBTD¡A预¦ô³Ì°ªÀ禬140»õ¬ü¤¸¡C

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2b¥Ø¼ÐÀø®Ä EASI 75, 73% vs Dupilumab 51% vs¹ï·Ó²Õ 15%

Àø®ÄÀu©ó¤G±iBTDªºdupilumab 40%(73% vs 51%)

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2022.5.10-Turning Point«Å¥¬repotrectinibÀò±o²Ä3­ÓBTD

2022.6.3-BMSªá41»õ¬ü¤¸¦¬ÁÊTurning Point

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ªvÀø¡]mITT¡^ªº¤H¸s¡A¨ä¤¤¤@­Ó¬ã¨s点ªº9¦W±wªÌ¦b¸Ñª¼«e³Q±qITT¤ÀªR¤¤±Æ°£¡C

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Efficacy analysis in the Phase 1b study used a modified Intent to

Treat (mITT) population in which 9 study patients from one site

were excluded from the ITT analysis prior to unblinding as the the

participants did not have disease characteristics consistent with

moderate to severe AD.

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aslanpharma.com/app/uploads/2022/09/EADV-2022-Biomarker-Poster_P0243_upload.pdf

Eblasakimab, a Monoclonal Antibody Targeting IL‑13R£\1 Reduces Serum Biomarkers Associated with

Atopy and Correlated with Disease Severity in Patients With Moderate‑to‑Severe Atopic Dermatitis

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Aslan Pharmaceuticals has an analyst consensus of Moderate Buy, with a price target consensus of $7.00.

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讨论

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·|­û¡G¤Ñ©R10141925  µoªí®É¶¡:2022/9/7 ¤U¤È 06:10:39²Ä 5542 ½g¦^À³
ASLAN Pharmaceuticals Presents New Data on Eblasakimab in Multiple Posters at the 31st Annual European Academy of Dermatology and Venereology (EADV) Congress

finance.yahoo.com/news/aslan-pharmaceuticals-presents-data-eblasakimab-100000503.html

Wed, September 7, 2022 at 6:00 PM

In this article:

ASLAN¨î药¤½¥q¦b²Ä31届欧¬w¥Ö肤¯f学©M©Ê¯f学学会¡]EADV¡^¦~会¤Wªº¦h张®ü报¤¤®i¥Ü¤FEblasakimabªº·s数Õu

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¥[¦{门¬¥©¬§J©M·s¥[©Y¡A2022¦~9¤ë7¤é¡]GLOBE NEWSWIRE¡^ -- ASLAN Pharmaceuticals¡]纳´µ达§J¡GASLN¡^¬O¤@®a处¤_临§É阶¬q¡B专ª`¤_§K¬Ì学ªº¥Íª«¨î药¤½¥q¡A¥¿¦b开发§ï变±wªÌ¥Í¬¡ªº创·s疗ªk¡A¤µ¤Ñ«Å¥¬¦b·N¤j§Q¦Ì兰举¦æªº2022¦~欧¬w¥Ö肤¯f©M©Ê¯f学会¡]EADV¡^¦~会¤W¤½¥¬¤F·sªº¥ì¥¬©Ô¦è单§Ü数Õu¡C¦b2022¦~9¤ë7¤é¦Ü10¤éªº¾ã个¤j会´Á间¡A将¦³¤T张®ü报¥H电¤l®ü报ªº§Î¦¡®i¥Ü¡C

这¨Ç®ü报¥]¬A¥H«e¥¼发ªíªº¥Íª«标§Óª«©M¥Í¬¡质¶q测¶q数Õu¡A¥H¤Î对¥H«e报¹Dªº¥ì¥¬©Ô¦è单§Üªv疗¤¤«×¦Ü­««×¯S应©Ê¥Öª¢¡]AD¡^ªº¦h级剂¶q1´Á¬ã¨s¤¤ªº临§É数Õu进¦æªº·sªº补¥R¤ÀªR¡C

ASLAN¨î药¤½¥q­º®u医疗©xAlex Kaoukhov评论说¡G·s´£¥Xªº¥Íª«标§Óª«数Õu为§Ú们¦beblasakimabªº1´Á试验¤¤观¹î¨ìªº临§É疗®Ä´£¨Ñ¤F¦³¤Oªº«È观¨ÌÕu¡A¦}¤ä«ù¨ä为AD±wªÌ´£¨Ñ©ú显®tÉݤƪv疗选择ªºýͤO¡C§Ú们¦b8©Pªº¬ã¨s´Á内观¹î¨ìæ±Ö}©MºÎ¯v¤£¨¬ªº©ú显§ïµ½¡A这ªí©ú随þÓªv疗时间ªº©µ长¦³¥i¯à产¥Í§ó¤jªº®ÄªG¡A§Ú们¥¿¦b进¦æªº2b´Á¬ã¨s¤¤对¦¹进¦æ¬ã¨s¡C总ªº来说¡A¦bEADV¤W®i¥Üªº数Õu给¤F§Ú们Ìå¤jªº«H¤ß¡A¦b¥¼来继续¬ã¨seblaskaimab¦bAD©M¨ä¥LÓì应¯g¤¤ªº§@¥Î¡C

2022¦~EADV电¤l®ü报详±¡

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ASLAN PHARMACEUTICALS LIMITED

Data presented at EADV for the first time show eblasakimab suppresses downstream inflammatory biomarkers of atopic dermatitis, continuing 4-6 weeks after the last dose

Notable improvements in quality-of-sleep measures, with fewer patients reporting sleep disturbance on eblasakimab

Eblasakimab significantly reduced P-NRS (itch) scores and improvements continued throughout 8-week course of treatment across all dose cohorts

MENLO PARK, Calif. and SINGAPORE, Sept. 07, 2022 (GLOBE NEWSWIRE) -- ASLAN Pharmaceuticals (NASDAQ: ASLN), a clinical-stage, immunology-focused biopharmaceutical company developing innovative treatments to transform the lives of patients, today announced the presentation of new eblasakimab data at the 2022 European Academy of Dermatology and Venereology (EADV) annual congress in Milan, Italy. Three posters are being presented as e-posters throughout the duration of the congress from September 7 to 10, 2022.

The posters include previously unpublished data on biomarkers and quality-of-life measures, and new, additional analyses of clinical data from the previously reported Phase 1 multiple-ascending dose study of eblasakimab in moderate-to-severe atopic dermatitis (AD).

Alex Kaoukhov, Chief Medical Officer, ASLAN Pharmaceuticals, commented, ¡§The newly presented biomarker data provide a robust, objective basis for the clinical efficacy we observed in the Phase 1 trial of eblasakimab and support its potential to offer a clearly differentiated treatment option for AD patients. We observed significant improvements in itch and sleep loss within the 8-week study period, suggesting the potential for a greater magnitude of effect with prolonged treatment and we are investigating this in the ongoing phase 2b study. Collectively, the data being presented at EADV gives us great confidence to continue investigating eblaskaimab¡¦s role in AD and other indications in the future.¡¨

2022 EADV e-poster details

Poster 1 (Poster #0243)

Eblasakimab, a monoclonal antibody targeting IL-13R£\1, reduces serum biomarkers that are associated with atopy and correlated with disease severity, in patients with moderate-to-severe atopic dermatitis

Discussion

AD is a skin disease with a predominant Type-2-inflammatory signature. Signaling through the Type 2 receptor induces expression of a multitude of marker molecules, correlating with disease severity. Marker molecules such as thymus activation regulated cytokine (TARC/CCL17), immunoglobulin E (IgE), and lactate dehydrogenase (LDH) are elevated in patients with severe disease. The poster shows results of patient samples from the proof-of-concept (PoC) trial of eblasakimab in adults with moderate-to-severe atopic dermatitis. Samples were immunoassayed for serum TARC, IgE and tested for LDH.

Results

Eblasakimab treatment reduced circulating levels of TARC/CCL17, IgE, and LDH, suggesting eblasakimab¡¦s unique mechanism of action targeting IL-13R£\1 and blocking the signaling of IL-4 and IL-13 through the Type 2 receptor is associated with reduced expression of the biomarker molecules associated with disease severity in AD1. Reductions from baseline were observed as early as the first post-baseline assessment for TARC/CCL17 (day 4), IgE (day 15) and LDH (day 15), with a rapid onset and significant difference at week 8 between 600 mg vs placebo for TARC/CCL17 (mean values of ‑62.23 vs ‑17.83, P<0.001). Serum biomarkers generally remained suppressed in the eblasakimab groups for four to six weeks following the last dose.

Poster 2 (Poster #0342)

Eblasakimab improves itch and sleep loss in adult patients with moderate-to-severe atopic dermatitis in a randomized, double-blinded, placebo-controlled, Phase 1 study

Discussion

Chronic itch is a hallmark of AD and occurs in over 80% of patients with the disease2. Itch is the most burdensome symptom reported by patients and is strongly linked to sleep disturbances; in the general population, up to 48% of adults experience sleep disturbances, but in adults with AD this figure is up to 90%3. The poster presents patient reported outcomes from the PoC trial of eblasakimab in adults with moderate-to-severe atopic dermatitis and includes analyses of pruritus numeric rating scale (P-NRS) and Patient Oriented Eczema Measure (POEM) with a single sleep loss component.

Results

Eblasakimab significantly reduced P-NRS scores across all dose cohorts in the modified Intent to Treat (mITT) population and improvements continued throughout the 8-week course of treatment. At week 8, patients in the 600mg dose group showed a 48% improvement in worst itch, versus a 13% improvement in the placebo group (P=0.05). 56% of patients in the 600mg eblasakimab group demonstrated at least a two point mean improvement in sleep loss, a clinically significant improvement in sleep loss, versus 15% in the placebo group.

Poster 3 (Poster #0343)

Eblasakimab improves multiple disease measures in adult patients with moderate-to-severe atopic dermatitis in a randomized, double-blinded, placebo-controlled, Phase 1 study

Discussion

The poster presents results on assessments of clinical signs of AD from the randomized, placebo controlled, double-blinded Phase 1 PoC trial of eblasakimab in adults with moderate-to-severe AD and highlights improvements in disease measures after treatment with eblasakimab. Efficacy assessments include changes in eczema area and severity index (EASI), Investigators Global Assessment (IGA) and Body Surface Area (BSA) score. Patients in the mITT population received eblasakimab at 200 mg (N=4), 400 mg (N=6), 600 mg (N=16) or placebo (N=13).

Results

In the mITT population, significant improvements in EASI score were seen early and progressed throughout the trial compared with placebo, with the 400mg and 600mg dose cohorts producing a greater response than the 200mg dose. At week 8, significant improvements were noted in the mean percentage change from baseline in EASI score in the 600mg group versus placebo (65% vs 27%, P=0.014), and 69% of patients achieved EASI-75 in the eblasakimab 600mg dose group versus 15% on placebo (P=0.005). Eblasakimab was well tolerated with notable improvements also seen in IGA versus placebo (44% vs 15%) in the 600mg group at week 8.

The posters presented at the conference are available to access here.

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Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

www.nejm.org/doi/full/10.1056/nejmoa1610020

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The atopic dermatitis (AD) market is expected to grow from a value of $6.4 billion in 2020 to $16.8 billion in 2030 in the seven major markets at a compound annual growth rate (CAGR) of 10.1%, according to GlobalData.

www.thepharmaletter.com/article/growth-in-atopic-dermatitis-market-to-exceed-10-at-cagr

2022/04/05

Ramla Salad, healthcare analyst at GlobalData, said: ¡§Biologics are expected to retain a large market share during the forecast period for the treatment of moderate to severe AD. Dupixent (dupilumab) is anticipated to be market leader with estimated peak sales of $6.2 billion in 2030. Furthermore, it is already known as the gold standard for the treatment of moderate to severe AD across the 7MM.¡¨

GlobalData expects that upcoming interleukin (IL) inhibitors - LEO Pharma¡¦s Adtralza/Adbry (tralokinumab), Eli Lilly¡¦s (NYSE: LLY) lebrikizumab, and Galderma¡¦s nemolizumab - will take market share from Sanofi (Euronext: SAN) and Regeneron¡¦s (Nasdaq: REGN) Dupixent and other immunomodulators over the forecast period as they are all targeting the moderate to severe patient population, with combined 2030 sales of $2.2 billion.

Innovation on the way

Oral JAK inhibitors are also expected to see strong growth during the forecast period with combined sales of $3.5 billion, and AbbVie¡¦s (NYSE: ABBV) Rinvoq (upadacitinib) leading the pack.

Amgen (Nasdaq: AMGN) and Kyowa Kirin¡¦s (TYO: 4151) anti-OX40 inhibitor, KHK4083, and Pfizer¡¦s (NYSE: PFE) sphingosine-1-phosphate receptor (S1PR) modulator, etrasimod, are two new therapies in the late-stage development and hold huge promise.

Ms Salad said: ¡§Based on insight from key opinion leaders (KOLs) interviewed by GlobalData, enthusiasm for these late-stage agents is due to their new mechanisms of action and the innovation they would bring to the market; if approved they would both be the first in their respective classes.¡¨

An increasing uptake of topical therapies for the treatment of mild to moderate AD is expected to greatly improve the overall control of flare-ups and consequently decrease the use of traditional therapies such as topical corticosteroids (TCS) and topical calcineurin inhibitors (TCI).

Notable therapies include topical JAKs, Incyte¡¦s (Nasdaq: INCY) Opzelura (ruxolitinib) and LEO Pharma¡¦s Corectim (delgocitinib) and phosphodiesterase-4 (PDE-4) inhibitors, AstraZeneca¡¦s (LSE: AZN) roflumilast and Otsuka Pharmaceutical¡¦s (TYO: 4578) Moizerto (difamilast). Peak sales for topical JAK and PDE-4 inhibitors are expected to reach combined sales of $630.6 million.

¡¦Very dynamic space¡¦

Ms Salad added: ¡§The AD market is a very dynamic space as exemplified by the pipeline activity, but there are some barriers to growth which could limit the uptake of these therapies. Pipeline topical JAK inhibitors will be entering a considerably competitive landscape where more expensive options, such as Eucrisa (crisaborole), are struggling to increase patient uptake. While KOLs were excited at the prospect of new pipeline drugs, many of them have a high ACOT, which will prevent uptake. As a result, physicians are likely to continue prescribing TCs, TCIs, and systemic immunomodulators.

¡§Although these barriers will have some impact on growth, the market is expanding at an impressive rate and ample opportunities exist for developers to further improve the AD treatment landscape for all ages and severities.¡¨

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The U.S. Food and Drug Administration (FDA) granted lebrikizumab Fast Track designation in AD in December 2019

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2016 ¦~ 9 ¤ë 26 ¤é ÁÉ¿Õµá (Sanofi) ©M¦A¥Í¤¸ (Regeneron) «Å¥¬ Dupilumab ¥Íª«»s«~³\¥i¥Ó½ÐÀò¬ü°ê FDA ±µ¨üÀu¥ý¼f¬d

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Date Article

Jun 7, 2022 Approval FDA Approves Dupixent (dupilumab) as First Biologic Medicine for Children Aged 6 Months to 5 Years with Moderate-to-Severe Atopic Dermatitis

May 20, 2022 Approval FDA Approves Dupixent (dupilumab) as First Treatment for Adults and Children Aged 12 and Older with Eosinophilic Esophagitis

Oct 20, 2021 Approval FDA Expands Approval of Dupixent (dupilumab) to Include Children Aged 6 to 11 Years with Moderate-to-severe Asthma

Jun 19, 2020 Approval FDA Approves New Dupixent (dupilumab) Pre-Filled Pen Designed to Support More Convenient Self-Administration

May 26, 2020 Approval FDA Approves Dupixent (dupilumab) as First Biologic Medicine for Children Aged 6 to 11 Years with Moderate-to-Severe Atopic Dermatitis

Jun 26, 2019 Approval FDA Approves Dupixent (dupilumab) for Chronic Rhinosinusitis with Nasal Polyposis

Mar 11, 2019 Approval FDA Approves Dupixent (dupilumab) for Moderate-to-Severe Atopic Dermatitis in Adolescents

Oct 19, 2018 Approval FDA Approves Dupixent (dupilumab) for Moderate-to-Severe Asthma

Mar 28, 2017 Approval FDA Approves Dupixent (dupilumab) for Eczema

Sep 26, 2016 Sanofi and Regeneron Announce Dupilumab Biologics License Application Accepted for Priority Review by U.S. FDA

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ASLAN PHARMACEUTICALS SIGNS LICENSE AGREEMENT WITH BELLE.AI TO USE BELLESTUDY™ IMAGE CAPTURE SOFTWARE IN ATOPIC DERMATITIS CLINICAL TRIALS

MENLO PARK, Calif. and SINGAPORE and CAMBRIDGE, Mass., Aug. 25, 2022 /PRNewswire/ -- BelleTorus Corporation (Belle.ai) and ASLAN Pharmaceuticals (Nasdaq: ASLN), today announced that ASLAN has licensed belleStudy™ digital image capture software in support of ASLAN¡¦s clinical trials for atopic dermatitis (AD) across several global sites. ASLAN will make the image capture software component of belleStudy™ available to all investigators of TREK-AD, its ongoing global phase 2b trial of eblasakimab, expected to generate topline data in the first half of 2023.

Belle.ai provides ASLAN and the investigators participating in our global studies with an easy-to-use solution that collects a standardized record of AD disease severity through image capture. This technology allows us to enhance our quality control procedures without having to adjust our protocols in this ongoing study, said Dr. Alex Kaoukhov, Chief Medical Officer, ASLAN Pharmaceuticals. We believe it can be a powerful tool for investigators, allows ongoing review of objective photographic evidence of disease severity assessment at the clinical trial site and will augment the current imaging methods used in our studies.

The belleStudy™ image capture software on a smartphone camera guides clinical investigators to clearly and accurately capture photos of AD before being uploaded to a cloud. Belle.ai¡¦s precise AI algorithms provide qualitative assessment (identification) and quantitative scoring (severity) of atopic dermatitis and over 1,000 skin conditions, delivering cutting edge digital solutions which could be leveraged by ASLAN in future AD studies.

The future of decentralized clinical trials is putting powerful and easy-to-use AI tools in the hands of investigators to capture clinical data from anywhere in the world, and we are pleased to be able to do this for ASLAN Pharmaceuticals, added Dr. Cliff Perlis, Chief Medical Officer of Belle.ai. Our technology can also be used directly by patients, who can track treatment progress in the privacy of their own homes and collect data accurately and uniformly, which adds an unlimited stream of data critical to clinical endpoints.

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ASLAN PHARMACEUTICALS LIMITED

Mon, August 22, 2022 at 7:00 PM

In this article:

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ASLAN PHARMACEUTICALS LIMITED

ASLAN PHARMACEUTICALS LIMITED

Management team will host R&D day on Thursday, September 15, from 10am ET in New York City with Key Opinion Leader (KOL) participation

Pipeline and business update, translational and clinical data on eblasakimab in development for moderate-to-severe atopic dermatitis (AD) and other topics related to the AD landscape to be discussed with a live webcast option

MENLO PARK, Calif. and SINGAPORE, Aug. 22, 2022 (GLOBE NEWSWIRE) -- ASLAN Pharmaceuticals (Nasdaq: ASLN), a clinical-stage, immunology-focused biopharmaceutical company developing innovative treatments to transform the lives of patients, today announced that it will be hosting a R&D Day on Thursday, September 15, 2022, from 10:00am to 1:30pm ET at the St. Regis Hotel in New York, NY.

The event will include presentations from management as well as Key Opinion Leaders (KOLs) in dermatology, Peter A. Lio, MD of Northwestern University Feinberg School of Medicine, and Shawn Kwatra, MD of Johns Hopkins University, who will discuss the emerging unmet needs, therapeutic landscape and molecular mechanisms underlying AD.

ASLAN¡¦s leadership team including Carl Firth PhD (Founder and CEO), Stephen Doyle (Chief Business Officer), Alex Kaoukhov MD (Chief Medical Officer), and other members of the senior R&D management team will discuss the pipeline portfolio led by eblasakimab, a potential novel, first-in-class monoclonal antibody that targets the IL-13 receptor £\1 subunit (IL-13R£\1) being developed for the treatment of moderate-to-severe AD.

The event will provide a comprehensive update on the eblasakimab development program, including:

Translational data on eblasakimab¡¦s unique mechanism of action

Clinical data from the Phase 1b proof-of-concept study of eblasakimab

Overview of eblasakimab¡¦s development strategy and path to market

Update on the latest in AD research

Formal presentations will be followed by a KOL panel discussion.

To attend the event in person or virtually, please click here for registration. For in-person attendance, please register in advance as space is limited. A replay of the event and presentation materials will be available on the Investor Relations section of ASLAN¡¦s website at ir.aslanpharma.com/

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²³ø²Ä16­¶004¹ï©óIL-13R£\1ªºµ²¦X¤O¤j©óIL-13¨üÅé¬ù60­¿¡A³o¼Ëªº¯SÂI¬O¥i¯àĹ¹L§ù¥²ª¢ªº§Q¾¹¡A­Y¥H¤U¨â²Õ¸ÕÅç¯à§e²{ªvÀøªº²Î­p·N¸q¨Ã¦bEASIĹ¹L¦Ñ§ù¡A´N¯à·íKing of A.DªvÀø~~~´Á«Ý2B´Á¤¤¼Æ¾Ú¤Î¸Ñª¼«á³o¨â²Õ¸ÕÅ窺¤ÀªR~~~¥[ªoªü·à

Experimental-3: ASLAN004 400 mg every four weeks (q4w)

ASLAN004 400 mg q4w - loading doses at Baseline, Week 1 and Week 2, followed by regular doses of 400 mg or alternating placebo (q2W) to Week 14.

Experimental-4: ASLAN004 600 mg q4w

ASLAN004 600 mg q4w - loading doses at Baseline, Week 1 and Week 2, followed by regular doses of 600 mg ASLAN004, alternating with placebo dose equivalents, q2W from Week 4 to Week 14.

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EASI75 Àø®Ä PK---­×1

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Solo 1 51%(¹êÅç²Õ) VS 15%(¹ï·Ó²Õ)(51%-15%=36%, 51%/15%=3.4)

Solo 2 44%(¹êÅç²Õ) VS 12%(¹ï·Ó²Õ)(44%-12%=32%, 44%/12%=3.7)

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¤T.ASLAN004 2b EASI75 Àø®Ä(2¶g¤@°w)---¹w¦ô

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EASI75 Àø®Ä PK

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Solo 2 44%(¹êÅç²Õ) VS 12%(¹ï·Ó²Õ)(44%-12%=32%, 44%/12%=3.7)

¤G.Lebrikizumab ¤T´Á EASI75 Àø®Ä(2¶g¤@°w)

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ASLAN004 2b EASI75Àø®Ä ³]­p¦ô:

1B EASI75 Àø®Ä­ì³]­p¦ô:

= A²Õ(°ò½u/¤¤µý=EASI31):11¤H/16¤H=69% +

B²Õ(°ò½u/»´¯gEASI=19): 5¤H/6¤H=83%--)

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¨Ï±oITT¤ÀªR EASI75

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VS ¹ï·Ó²Õ13%

---------------------------------------

2022¦~6¤ë7¤é ASLN CEO «Å§i: 2bÁ{§É¿z¿ï®É±N¥ý±Æ°£«D¶Ç²ÎAD±wªÌ­n©M

Dupilumab ¤T´ÁÁ{§É¤@¼Ëªº±wªÌ²Õ¦¨µ²ºc(¥i¯à¥ý±Æ°£«D¶Ç²ÎAD±wªÌ,§CEASI/§CIgE/§CTRAC²Õ¥u¦³0%~3%ªº¾÷²v).

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Lebrikizumab 2b, EASI75=60% VS 24%(¹ï·Ó²Õ),

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Dupilumab ¤T´Á¹êÅç²Õ

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------------------------------------------

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Large investors have recently bought and sold shares of the company. Waterfront Wealth Inc. acquired a new position in shares of ASLAN Pharmaceuticals in the 4th quarter valued at $302,000. Millennium Management LLC boosted its position in shares of ASLAN Pharmaceuticals by 2.8% in the 2nd quarter. Millennium Management LLC now owns 1,613,113 shares of the company¡¦s stock valued at $804,000 after purchasing an additional 43,949 shares during the period. Renaissance Technologies LLC lifted its stake in ASLAN Pharmaceuticals by 574.1% in the 2nd quarter. Renaissance Technologies LLC now owns 475,896 shares of the company¡¦s stock worth $236,000 after acquiring an additional 405,296 shares in the last quarter. Bank of America Corp DE lifted its stake in ASLAN Pharmaceuticals by 34.4% in the 1st quarter. Bank of America Corp DE now owns 259,722 shares of the company¡¦s stock worth $233,000 after acquiring an additional 66,544 shares in the last quarter. Finally, GSA Capital Partners LLP purchased a new stake in shares of ASLAN Pharmaceuticals during the 4th quarter worth about $89,000. Institutional investors own 38.65% of the company¡¦s stock.

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Experimental 3: ASLAN004 400 mg every four weeks (q4w)

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Aslan Pharmaceuticals Price Target Cut to $7.00/Share From $8.00 by HC Wainwright & Co.

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Aslan Pharmaceuticals Is Maintained at Buy by HC Wainwright & Co.

HC Wainwright&Co.¹ïªü´µÄõ»sÃĤ½¥qºû«ù¡¨¶R¶i¡¨«Øij.

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www.nejm.org/doi/full/10.1056/nejmoa1610020

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Lebrikizumab 2b ¸Ñª¼¤é¤½¥¬¡G2019¦~2¤ë7¤é

¼Ú¬w±ÂÅv ÀH«á7¤é¤½¥¬¡C2¤ë14¤é

A Study of Lebrikizumab (LY3650150) in Participants With Moderate-to-Severe Atopic Dermatitis

Study Design

Go to sections

Study Type : Interventional (Clinical Trial)

Actual Enrollment : 280 participants

Allocation: Randomized

Intervention Model: Parallel Assignment

Masking: Triple (Participant, Investigator, Outcomes Assessor)

Primary Purpose: Treatment

Official Title: A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Trial to Evaluate the Efficacy and Safety of Lebrikizumab in Patients With Moderate-to-Severe Atopic Dermatitis

Actual Study Start Date : January 30, 2018

Actual Primary Completion Date : February 7, 2019

Actual Study Completion Date : May 23, 2019

www.clinicaltrials.gov/ct2/show/NCT03443024

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www.sec.gov/edgar/search/?r=el#/q=Dermira

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This is a summary of current recommendations for ASLAN Pharmaceuticals and Geron, as provided by MarketBeat.com.

³o¬OMarketBeat.com´£¨Ñªº¹ïAslan PharmPharmticals©MGeron¨â¤äªÑ²¼ªº·í«e«ØijºK­n¡C

ASLAN Pharmaceuticals currently has a consensus target price of $5.50, indicating a potential upside of 548.58%. Geron has a consensus target price of $4.50, indicating a potential upside of 91.49%. Given ASLAN Pharmaceuticals¡¦ higher possible upside, analysts plainly believe ASLAN Pharmaceuticals is more favorable than Geron.

ªü´µÄõ»sÃĥثeªº¦@Ãѥؼлù¬°5.5¬ü¤¸¡Aªí©ú¼ç¦b¤W¦æªÅ¶¡¬°548.58%¡CGeronªº´¶¹M¥Ø¼Ð»ù¬°4.50¬ü¤¸¡A

ªí©ú¼ç¦b¤W¦æªÅ¶¡¬°91.49%¡C¦Ò¼{¨ìªü´µÄõ»sÃħ󦳥i¯à¤W¦æ¡A¤ÀªR®vÅãµM»{¬°ªü´µÄõ»sÃĤñGeron§ó¦³§Q¡C

ASLAN Pharmaceuticals has a beta of 1.91, indicating that its stock price is 91% more volatile than the S&P 500. Comparatively, Geron has a beta of 0.94, indicating that its stock price is 6% less volatile than the S&P 500.

ªü´µÄõ»sÃĪº¨©¶ð«Y¼Æ¬°1.91¡Aªí©ú¨äªÑ»ùªºªi°Ê©Ê¤ñ¼Ð·Ç´¶º¸500«ü¼Æ°ª¥X91%¡C

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ASLAN Pharmaceuticals has higher revenue and earnings than Geron. Geron is trading at a lower price-to-earnings ratio than ASLAN Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

ªü´µÄõ»sÃĪº¦¬¤J©M¦¬¯q¤ñGeron§ó°ª¡C

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ASLAN Pharmaceuticals beats Geron on 8 of the 14 factors compared between the two stocks.

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1.ASLAN

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Anticipated upcoming milestones

Three abstracts with new data on biomarkers and patient reported outcome measures from the Phase 1b proof-of-concept trial of eblasakimab have been accepted for e-poster presentation at the 31st EADV Annual Congress held in person and virtually, from September 7 to 10, 2022, in Milan, Italy.

The Company will host a Research and Development (R&D) Day on September 15, 2022, with a hybrid in-person and virtual format. More information will be announced in the weeks ahead.

Topline data from the Phase 2b TREK-AD trial of eblasakimab is expected in the first half of 2023.

Second quarter 2022 financial highlights

Cash used in operating activities for the second quarter of 2022 was US$9.7 million compared to US$6.9 million in the same period in 2021.

Cash, cash equivalents and short-term investments as of June 30, 2022, were US$78.1 million.

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MENLO PARK, Calif. and SINGAPORE, Aug. 11, 2022 (GLOBE NEWSWIRE) -- ASLAN Pharmaceuticals (NASDAQ: ASLN), a clinical-stage, immunology-focused biopharmaceutical company developing innovative treatments to transform the lives of patients, today announced that three abstracts, showcasing new findings related to eblasakimab, will be displayed as e-posters throughout the 31st European Academy of Dermatology and Venereology (EADV) Congress, to be held in-person and virtually from September 7 to 10, 2022, in Milan, Italy.

31st European Academy of Dermatology and Venereology Congress e-poster details

Poster 1: Eblasakimab improves multiple disease measures in adult patients with moderate-to-severe atopic dermatitis in a randomized, double-blinded, placebo-controlled, Phase 1 study

(abstract ID: #2464, poster ID: P0343)

Poster 2: Eblasakimab, a monoclonal antibody targeting IL-13Ra1, reduces serum biomarkers that are associated with atopy and correlated with disease severity, in patients with moderate-to-severe atopic dermatitis

(abstract ID: #932, poster ID: P0243)

Poster 3: Eblasakimab improves itch and sleep loss in adult patients with moderate-to-severe atopic dermatitis in a randomized, double-blinded, placebo-controlled, Phase 1 study

(abstract ID: #2459, poster ID: P0342)

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(Abstract ID: #2464, poster ID: P0343)

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(Abstract ID: #932, poster ID: P0243)

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(Abstract ID: #2459, poster ID: P0342)

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Study Design

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Study Type : Interventional (Clinical Trial)

Estimated Enrollment : 120 participants

Allocation: N/A

Intervention Model: Single Group Assignment

Masking: None (Open Label)

Primary Purpose: Treatment

Official Title: An Open-Label, Study to Evaluate the Safety and Efficacy of Lebrikizumab in Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis Previously Treated With Dupilumab

Estimated Study Start Date : August 18, 2022

Estimated Primary Completion Date : August 2, 2023

Estimated Study Completion Date : December 6, 2023

clinicaltrials.gov/ct2/show/NCT05369403?term=Lebrikizumab&draw=2&rank=3

A Study of Lebrikizumab (LY3650150) in Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis Previously Treated With Dupilumab

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Inclusion Criteria:

All participants must have prior treatment with dupilumab meeting one of the following conditions:

Participants who stopped dupilumab treatment due to non-response, partial response, loss of efficacy must have been previously treated with dupilumab (at labeled dose level) for at least 4 months.

Participants who stopped dupilumab treatment due to intolerance or adverse events (AEs) to the drug may enter the study with no required prior length of dupilumab treatment.

Participants who stopped dupilumab treatment due to cost or loss of access to dupilumab (for example, insurance coverage) may enter the study with no required prior length of dupilumab treatment.

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